Ealing Trailfinders will have to beat in-form Hartpury University if they are to recover the form they showed during the first half of the season.
The Trailfinders began 2023 with their first defeat of the season against Caldy, before bouncing straight back last weekend with a 35-24 win over Ampthill.
Their opposition at the Alpas Arena this weekend will not be a pushover as they play a Hartpury side who have won five straight matches as they have climbed up to fifth in the RFU Championship table.
Kick-off at the Alpas Arena is at 2:30pm on Saturday.
Harlequins will be hoping to maintain their perfect home record in the European Champions Cup as they host Sharks in their fourth group stage match.
The Quins were beaten by a single point away against Racing 92 last weekend as they lost their second away match of the group stage, but they did win their home opener in this competition against the French side.
This time they face South African-outfit Sharks, who have won three out of three to open their pools campaign, including a win against Harlequins in December in Durban.
Kick-off at the Twickenham Stoop is at 1pm on Saturday.
London Scottish are still in search of their first win of the new year as they travel to face second-top Jersey Reds in the RFU Championship.
Scottish remain bottom of the table as they fell away in the second half of last week's clash against Bedford Blues to make it 11 defeats this season.
Jersey Reds are challenging at the opposite end of the table as they sit five points behind Ealing Trailfinders at the summit of the RFU Championship, although they have not won since 14th December.
Kick-off at the Stade Santander International is at 3pm on Saturday.
London Welsh face a fight to follow up their strong performance last weekend as they take on a Bracknell side directly below them in the table.
Welsh went from giving up 41 points against Havant to scoring 42 points last week against Sutton and Epsom as they recorded a big win to break a three-match losing run.
Bracknell are sat in seventh in Regional One South Central, one place behind London Welsh, and they have won their last two home games, but their away form has not matched in recent weeks.
Kick-off at Lily Hill Park is at 2pm on Saturday.
It is a top of the table clash for Teddington this weekend as they put their unbeaten record on the line away against third place Chipstead.
The Antlers put in one of their best performances of the season last weekend as they won 66-10 against Old Blues to win their 13th match of the season.
They travel to Chipstead who are in red hot form, having not lost since Teddington beat them at Bushy Park back in October and they have only given up more than 20 points once since then as well.
Kick-off at The Meads is at 2pm on Saturday.
Elsewhere in the area, London Irish are away against Montpellier on Sunday, Twickenham RFC host Old Tiffinians, and Kingston RFC are at home against Old Cranleighans.
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